Essay --

Participation of hyperglycaemia in triggering the multiple aerophilic tenor pathways in the course of diabetes. AngII angiotonin II eNOS endothelial nitric oxide synthase Jac/STAT janus kinase (Jac)-signal transducer and activator of organisation (STAT) LDL low compactness lipoprotein cholesterol MAPK mitogen-activated protein kinase MetS metabolic syndrome NF-b thermonuclear transcription factor b NO nitric oxide NOS nitric oxide synthase O2 superoxide anion anion total OH hydroxyl radical ONOO peroxynitrite PCK protein kinase C . Adapted from Johansen et al., 2005 The increased oxidative stress in subjects with oddball 2 diabetes is therefore a magnitude of several abnormalities, including hyperglycemia, insulin resistance, hyperinsulinemia, and dyslipidemia, each of which contributes to mitochondrial superoxide overproduction in endothelial cells of large-mouthed and small vessels as wellhead as the myocardium15COMPLICATIONS OF DIABETES Whether diabetes occurs as a o utgrowth of type 1, the early-onset and predominantly insulin-dependent form, or type 2, the late-onset... Essay -- Participation of hyperglycemia in triggering the multiple oxidative stress pathways in the course of diabetes. AngII angiotensin II eNOS endothelial nitric oxide synthase Jac/STAT janus kinase (Jac)-signal transducer and activator of transcription (STAT) LDL low density lipoprotein cholesterol MAPK mitogen-activated protein kinase MetS metabolic syndrome NF-b nuclear transcription factor b NO nitric oxide NOS nitric oxide synthase O2 superoxide anion radical OH hydroxyl radical ONOO peroxynitrite PCK protein kinase C . Adapted from Johansen et al., 2005 The increased oxidative stress in subjects with type 2 diabetes is therefore a magnitude of several abnormalities, including hyperglycemia, insulin resistance, hyperinsulinemia, and dyslipidemia, each of which contributes to mitochondrial superoxide overproduction in endothelial cells of large and small v essels as well as the myocardium15COMPLICATIONS OF DIABETES Whether diabetes occurs as a result of type 1, the early-onset and predominantly insulin-dependent form, or type 2, the late-onset...